What principle demands informed decision-making for research subjects?

The principle that demands informed decision-making for research subjects is rooted in the concept of "Respect for persons." This principle emphasizes the importance of recognizing the intrinsic worth of individuals and ensuring that they are treated as autonomous agents capable of making their own informed decisions. Informed consent is a key aspect of this principle, as it requires that individuals are provided with comprehensive information regarding the research, including its purpose, risks, benefits, and alternatives, allowing them to make knowledgeable choices about their participation.

By adhering to the principle of Respect for persons, researchers honor the autonomy of participants, which enhances ethical practices within research contexts. This ensures that the rights and dignity of individuals are safeguarded, fostering a trust-based relationship between researchers and subjects.

While autonomy is indeed associated with decision-making, it is more of a component within the broader framework of Respect for persons, rather than a distinct principle. Beneficence focuses on maximizing benefits and minimizing harm, while justice involves fair distribution of the benefits and burdens of research. Therefore, the emphasis on informed decision-making is specifically tied to the principle of Respect for persons.